RUTH – IRB Submission System


MSHS Institutional Review Board (IRB) submission.


Institutional Review Board (IRB)


  • Single Sign On Access
    • Use your Mount Sinai email and Network ID password. Starting October 29, 2020, RUTH users who do not have their Mount Sinai email address in Sinai Central will not be able to access the system. Sinai-approved email addresses include the following domain suffixes:,,,,,,, and Click here for instructions on how to update your contact information in Sinai Central.
    • Off-campus Access – RUTH is cloud-based so VPN /Tunnel is not required to gain access.
  • Upload CVs
    • All members of the study team must upload their CV in RUTH under My Profile. For detailed guidance, refer to q guide ruth.
    • The uploaded CV must list the current position held at MSHS.
  • Assigning Proxies
    • Only the PI can assign a proxy to a project. The proxy will have the authority to make changes and submit all projects (initial, continuing reviews, modifications) on behalf of the PI once assigned. As a reminder to all Principal Investigators, a signature by your proxy is considered to be the same as your personal signature. Oversight of the project including submission to the PPHS is the responsibility of the PI.
    • For detailed guidance, refer to q guide ruth.
  • Assigning a Primary Contact – For detailed guidance, refer to q guide ruth.
  • CITI Training Profiles
    • To ensure CITI training is transferred to RUTH, your CITI profile must include your Mount Sinai Life# and list a MSHS email as the primary email address
    • CITI Program > Log on > Profile > Update Institutional Profile > Employee ID #> Enter Your Mount Sinai Life # > Enter Your MSHS email as the Primary email

System Link



Technical Support Open a Ticket or email ESUPPORT@MSSM.EDU

IRB Support – RUTH via Add Comment or contact the PPHS Office.

PPHS Office
(212) 824-8200

IRB Virtual Office Hours
Mondays from 10:00 – 11:00 am
Wednesdays from 2:00 – 3:00 pm
Learn More

RUTH Training

Training Videos

Reference Guides

Library in RUTH

  • Standard Operating Procedures (SOPs)
  • Investigator Manual
  • Worksheets
  • Checklists
  • Templates

Help Center in RUTH

  • RUTH user guides
  • RUTH training videos

Research Administration IT

PPHS Naming Convention for Documents Uploaded in RUTH – Effective 02/01/2021


RUTH PPHS Communication Page

Research Listserv – Sign up to Research Listserv, the research administration email messaging system to receive the latest news and information including RUTH updates, funding opportunities, policy updates, and more.