Basic Science

Basic research is a key component of discovery at Mount Sinai, yielding fundamental new insights that are relevant to human biology and disease and cannot be predicted from current knowledge. Basic research at Mount Sinai spans a wide variety of topics including cell biology; cell-cell signaling pathways; stem cells and regeneration; drug mechanisms and addiction; brain development, degeneration, and disease; cancer mechanisms; and microbiology. Our researchers use human tissues and cells, and model systems such as mice, zebrafish, Drosophila, and Xenopus laevis, to probe developmental and disease processes, identify new therapeutic targets, and develop or identify disease-fighting vaccines and drugs. Basic research occurs both in the basic science Departments and Institutes, and in clinical Departments and is supported by state-of-the-art Core Facilities and Resources.