Dr. Guisado is a Pediatric IBD Translational Research Fellow. Her proposal is titled ‘Investigating the Hematopoietic Stem Cell Niche in Crohn’s Disease’. Her mentors will be: Louis Cohen, MD and Judy Cho, MD.
Dr. Guisado has been dedicated to biomedical research throughout her educational career and has honed skills in basic, clinical, and translational research. She recently completed her clinical training in pediatric gastroenterology fellowship at Mount Sinai and developed a passion for pediatric inflammatory bowel disease (IBD). During Dr, Guisado’s unique clinical experience during fellowship at Mount Sinai, she took care of many complex cases of IBD and she developed an interest in better understanding the underlying pathophysiology of CD, and specifically in the development of medically refractory CD. These questions drove her interest in doing research with Dr. Louis Cohen, her primary mentor, as she was fascinated by how patients with such medically refractory disease and severe complications could achieve clinical and endoscopic disease response and remission through SCT. Dr. Guisado has been dedicated to pursuing the answers to these questions by spending the last 3 years engaged in translational research in the laboratory of Dr. Cohen to investigate the mechanisms underlying the treatment response for SCT for CD. She has continued her investigations under a T32 training grant to further explore this research beyond the dedicated time that was given to her during her clinical fellowship. Through her initial research, she has identified for the first time that the HSC niche may be critical for the response to SCT through reconstitution of myeloid populations and signaling pathways to promote mucosal healing and hypothesizes that the HSC niche may play a critical role in CD pathophysiology and refractory CD. Dr. Guisado hopes that through this research, she can better understand the HSC niche in CD.
ConduITS is supported by NCATS of the NIH’s CTSA Program. Any use of CTSA-supported resources requires citation of grant number UL1TR004419 awarded to ISMMS in the acknowledgment section of every publication resulting from this support. Adherence to the NIH Public Access Policy is also required.
