Academic Informatics & Technology
Director – Paul Lawrence, MFA
Description
The Levy Library supports the education, research, and clinical information needs of the Mount Sinai Health System, including the Icahn School of Medicine at Mount Sinai. The Library is a unit of Mount Sinai’s Academic Informatics and Technology division.
Recent Grants – N/A
Recent Publications – N/A
BioMedical Engineering and Imaging Institute (BMEII)
Director – Zahi A Fayad, PhD
Description
The primary goal of BMEII is to develop unique approaches to biomedical sciences and therapeutic interventions by bridging basic and translational research and education by leveraging expertise in medicine and engineering. Engineering and engineering science are fundamentals to understanding the basic biomedical phenomena and associated therapeutic interventions. Major inventions and innovations that have shaped modern medicine were born out of close collaborations of engineers with biomedical researchers and clinicians, ranging from medical devices and highly sensitive and accurate bioimaging systems, to new drug target discovery and accelerated drug discovery. We have and we will continue to wisely and strategically invest in BMEII in order to lead in biomedical discovery, disease understanding and translation to patient care. By exploring our website you will learn how BMEII is unique due to its dual focus on research and education, the interrelationships between biomedical research and engineering, and spanning the molecular to human dimensions of biomedical research. I look forward to a future of advancing biomedical scientific discoveries thanks to the wonderful faculty, trainees, staff, and collaborators at BMEII.
Recent Grants – Studying Atherosclerosis Macrophage Dynamics by Combined PET and Fluorine-MRI (5T-R01-HL143814)
Recent Publications – CT Imaging Features of 2019 Novel Coronavirus (2019-nCoV)
Center for Biomedical and Population Health Informatics
Description
Center is focused on developing and implementing creative informatics solutions that improve access to heterogeneous biomedical data streams and catalyze data science; promoting personalized health informatics driven by social determinants of health and individualized patient profiles; using big data to support pioneering models of health care delivery; facilitating monitoring of health care quality; and preventing disease at individual, population, and global health levels.
Center for Biostatistics | Icahn School of Medicine
Director – Emilia Bagiella
Description
The Center for Biostatistics at the Icahn School of Medicine at Mount Sinai (ISMMS) reflects the Institutional commitment to advancing interdisciplinary translational and patient-oriented research by providing state-of-the-art statistical support to investigators.
Recent Grants – Hybrid Coronary Revascularization Trial- DCC (5T-U01-HL125506)
Recent Publications – Association of Treatment Dose Anticoagulation With In-Hospital Survival Among Hospitalized Patients With COVID-19
Center for Clinical Informatics | Icahn School of Medicine
Director – Bruce Darrow
Description
The mission of the Center for Clinical Informatics in the Department of Pathology, Molecular and Cell-Based Medicine is to educate, train, and develop the next generation of clinical informaticists and meet the workforce needs in health information technology and health care for the 21st century. Its vision is to establish the Center and the Clinical Informatics Fellowship training program as a national leader in training. To do so, we will leverage the strengths of Clinical Informatics at Mount Sinai, Informatics innovation, and the unique blend of operational and academic Informatics.
Its goal is to make Mount Sinai Health System a national leader for the training of Clinical Informatics Fellows and provide an academic home for Clinical Informatics Fellows, in collaboration with the Department of Medicine’s Division of General Internal Medicine. Our planned activities include Didactic Seminars, Journal Club, Guest Lecturers and Board Review.
Recent Grants – N/A
Recent Publications – PREDICTIVE MODELING OF HOSPITAL READMISSION RATES USING ELECTRONIC MEDICAL RECORD-WIDE MACHINE LEARNING: A CASE-STUDY USING MOUNT SINAI HEART FAILURE COHORT
Charles R. Bronfman Institute for Personalized Medicine
Director – Judy H Cho, MD
Description
Vision: A shared ecosystem of clinicians, neuroscientists and engineers will catalyze a new model of patient-focused research with the common goal to correct circuit abnormalities and restore mood, motor and cognitive function across diagnoses.
Recent Publications – A brief history of human disease genetics
Clinical Data Science | Mount Sinai Health System
Co-Directors – Matthew A. Levin, MD; Robbie Freeman, RN
Description
Data science, machine learning (ML) and artificial intelligence (AI) have the potential to transform the delivery of clinical care and improve patient outcomes. We have built a powerful real-time streaming clinical data platform that brings the power of ML and AI into the hospital. Our vision is to use this platform to improve early recognition and diagnosis of clinical conditions, improve provider awareness and timely intervention, and enhance hospital operations. AI allows us to gain new insights and continuously improve over time as the platform learns from our patients and clinicians. Read on below to find out more how Mount Sinai is leading the way in applying this technology to transform healthcare.
Website – Clinical Data Science | Mount Sinai Health System
Recent Grants – N/A
Recent Publications – Real-Time Machine Learning Alerts to Prevent Escalation of Care: A Nonrandomized Clustered Pragmatic Clinical Trial
Data Science and Genomic Technology
Director – Adam Margolin, PhD
Description
The mission of the Division of Medical Genetics and Genomics is to apply our expertise in understanding human genetic variation as it relates to health and disease across the lifespan. Our goals are to bring the highest quality of care possible to patients with genetic and genomic disorders and to individuals and families at risk for such disorders, from precise diagnostics to state of the art therapeutics. We strive to accomplish this mission while training the next generation of genetics and genomics professionals across multiple disciplines and in collaboration with practitioners from across the Mount Sinai Health System and beyond. We further commit to providing our patients access to cutting-edge research that will shed light on how genetic and genomic variation contributes to human disease and that will bring hope for new treatment options to our patients.
Recent Grants – N/A
Recent Publications – Svpluscnv: analysis and visualization of complex structural variation data
Department of Genetics and Genomic Sciences | Icahn School of Medicine
Director – Alison M Goate
Description
The mission of our Division of Medical Genetics and Genomics is to apply our expertise in understanding human genetic variation as it relates to health and disease across the lifespan. Our goals are to bring the highest quality of care possible to patients with genetic and genomic disorders and to individuals and families at risk for such disorders, from precise diagnostics to state of the art therapeutics. We strive to accomplish this mission while training the next generation of genetics and genomics professionals across multiple disciplines and in collaboration with practitioners from across the Mount Sinai Health System and beyond. We further commit to providing our patients access to cutting-edge research that will shed light on how genetic and genomic variation contributes to human disease and that will bring hope for new treatment options to our patients.
Recent Grants – Genetics and Genomics Core (1T-P30-AG066514P)
Recent Publications – The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer’s disease
Department of Population Health Science and Policy
Director – Annetine Gelijns, PhD
Description
To realize this mission requires the collaborative efforts of a broadly interdisciplinary faculty and the creation of investigative teams that focus on specific aspects of this research agenda. Integral to the Department are several divisions and three centers that serve the entire Mount Sinai Health System; they include the International Center for Health Outcomes and Innovation Research (InCHOIR), a clinical research coordinating center; the Center for Biostatistics; and the Center for Health Equity and Community Research.
The Department’s faculty also created and continues to direct the Institute for Health Care Delivery Science (IHCDS) and took on the leadership and transformation of the Institute for Translational Epidemiology (ITE). The mission of IHCDS is to develop, analyze, and disseminate evidence that can guide clinical decision-making toward improvements in the quality, safety, outcomes, and efficiency of care delivered in the Mount Sinai Health System. The mission of ITE is to develop and facilitate collaborative translational and interdisciplinary research integrating population studies, genomic and molecular research with the goal of spearheading improvements in clinical practice, disease management, patient outcomes, and quality of life.
Recent Grants – Network for Cardiothoracic Surgical Investigations in Cardiovascular Medicine(U5T-U01A-HL088942)
Recent Publications – Two-Year Outcomes of Surgical Treatment of Severe Ischemic Mitral Regurgitation
Digital Health | Icahn School of Medicine
Director – Yvonne Yu-Feng Chan MD, PhD
Description
The Center for Digital Health was founded by Director Yvonne Chan, MD in 2014, serving as an invaluable resource to the greater Mount Sinai Health System community as it meets the growing need for digital health technology research and development.
In 2015, in partnership with Sage Bionetworks and the Respiratory Institute at Mount Sinai, our team created the Asthma Mobile Health Application. The app was one of the original five launch partners to use Apple’s ResearchKit framework. In January 2018, working with Mount Sinai’s Institute of Personalized Medicine, the team released an electronic platform for eligible participants to consent and enroll in the BioMe Biobank program.
- Technology platforms developed for automation and digitalization of clinical processes
- Clinical research mobile app and website development
- Research study design and implementation
- Collaboration for the publication of research findings
- IRB and regulatory expertise
Recent Grants – N/A
Recent Publications – The Use of Smartphones for Health Research
Environmental Medicine and Public Health | Icahn School of Medicine
Director – Robert O Wright
Description
The Department of Environmental Medicine and Public Health at the Icahn School of Medicine at Mount Sinai has a long and distinguished tradition of excellence in clinical, translational, and basic research. Our research aims to better understand, treat, and prevent disease of environmental origin. We are national leaders in the study of the “exposome”—the lifetime environmental exposures of individuals, including those that occur even before birth, and how those exposures interact with a person’s unique genetic and physiological makeup. Our department encompasses the allied fields of environmental and occupational medicine, biostatistics, and behavioral science.
Recent Grants – Research Training Program in Environmental Pediatrics (5T-T32-HD049311)
Recent Publications – Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight
Hasso Plattner Institute for Digital Health at Mount Sinai
Hasso Plattner Institute for Digital Health at Mount Sinai
Director – Thomas Fuchs, PhD
Description
Science and technology have created tremendous opportunities to improve and extend our lives. At the Hasso Plattner Institute for Digital Health at Mount Sinai, we use the tools of data science, biomedical and digital engineering, and medical expertise to advance health care. The institute is a collaboration between the Hasso Plattner Institute for Digital Engineering in Potsdam, Germany, and the Mount Sinai Health System. Our goal is to develop innovations to revolutionize how people think about their personal health and health systems and have a tangible impact on patients’ lives.
The institute strives to develop research projects and artificial intelligence technologies to improve our ability to diagnose and treat patients. The Hasso Plattner Institute for Digital Health at Mount Sinai receives generous support from the Hasso Plattner Foundation. Below, we outline our research projects and machine learning efforts.
Recent Grants –Evaluation techniques for mHealth outcome measures using patient generated health data
Department Website – https://icahn.mssm.edu/about/departments/ai-human-health
Recent Publications – A machine learning approach to determine resilience utilizing wearable device data: analysis of an observational cohort
Institute for Exposomic Research Labs
Director – Rosalind Wright, MD
Description
The Mount Sinai Institute for Exposomic Research is the nucleus of the Icahn School of Medicine’s work on studying environmental exposures and their effects on life health, disease, and development. With our transdisciplinary research program, expertise, and analytical capabilities, we are designing innovative exposure measures and studying a vast array of health outcomes, from childhood to later life. These include childhood obesity, asthma, renal disease, cancer, autism, postpartum depression, learning disabilities, PTSD, and ALS (Lou Gehrig’s disease), as well as the health status of the World Trade Center responders cohort. We focus not only on finding causes of diseases but on what helps us maintain and improve our health at every stage of life. Our goal is to translate our findings into new strategies for prevention and treatment.
Recent Grants – Phenotyping and Environmental Modifier Facility Core
Recent Publications – Prenatal Particulate Air Pollution and DNA Methylation in Newborns: An Epigenome-Wide Meta-Analysis
The Institute for Genomic Health
The Institute for Genomic Health
Director – Eimear Kenny, PhD
Description
Population genetics explores genetic differences both within and between populations and individuals over time. This primarily encompasses the quantitative study of genotypes and phenotypes within the context of historical demography. Improved next-generation sequencing technologies, increased scalability in genetic data processing, and impressive global data-sharing initiatives provide unprecedented research opportunities, allowing us to understand the links between ancestry, genetics, and health outcomes.
Our overall goal is to characterize human genetic ancestry in order to inform better models for clinical medicine. We achieve this using advanced statistical and probabilistic modeling and inference to determine genetic associations, subpopulations, and relatedness.
Recent Grants – Genomic risk in clinic care to promote health equity in New York City patients (1T-U01-HG011176)
Recent Publications – Genetic analyses of diverse populations improves discovery for complex traits
Institute for Health Care Delivery Science
Director – Madhu Mazumdar, PhD
Description
The Institute for HealthCare Delivery Science is dedicated to improving the effectiveness, safety, and efficiency of patient care throughout the Mount Sinai Health System. While medical knowledge is increasing at an exponential rate, numerous studies have documented unexplained variations in practice and patient outcomes, with unacceptable rates of medical errors and inefficiencies in health care delivery nationwide. At the Institute, we are establishing new and innovative ways to measure the value of health care delivery and subsequently use this information to improve the effectiveness and efficiency of patient care.
Recent Grants – Biostatistics (2T-P30-CA196521)
Recent Publications – An inflammatory cytokine signature predicts COVID-19 severity and survival
Institute for Translational Epidemiology
Director – Emanuela Taioli, MD, PhD
Description
Epidemiology has undergone exciting transformations, as reflected by the new popular terminology “Integrative Epidemiology,” a definition that describes the cohesive, interdisciplinary, collaborative, and multilevel nature of the discipline.
The mission of the Institute for Translational Epidemiology at the Icahn School of Medicine is to develop and facilitate highly collaborative translational and interdisciplinary research integrating population studies, genomic and proteomic research, with the ultimate purpose of spearheading changes in clinical practice and improving the treatment of disease and patient quality of life.
Recent Grants – Thyroid Cancer Aggressiveness in WTC Responders (5T-U01-OH011849P)
Recent Publications – The Impact of Asthma on Mortality in Patients With COVID-19
Mount Sinai Center for Bioinformatics
Mount Sinai Center for Bioinformatics
Director – Avi Ma’ayan, PhD
Description
The focus is on analyzing, visualizing, and mining data from experiments that profile the molecular state of human cells and tissues by transcriptomics, epigenomics, proteomics, and metabolomics for drug discovery. We also explore how to integrate these datasets with genomics and electronic medical health records data to advance precision medicine.
In addition to developing algorithms, web-based software tools, and databases, and collaborating with wet-bench experimental laboratories at Mount Sinai, the center organizes courses, workshops, tutorials, and seminars; our Data Science MOOC and in-class courses for undergraduate and graduate students aim to train the next generation of Bioinformaticians.
Recent Grants – KNOWLEDGE MANAGEMENT CENTER FOR ILLUMINATING THE DRUGGABLE GENOME
Recent Publications – Single-cell immune landscape of human atherosclerotic plaques
Mount Sinai Center for Transformative Disease Modeling
Director – Bin Zhang, PhD
Description
Goals: To build upon these novel insights and accelerate the development of next-generation therapeutics.
To use a number of research directions to support and facilitate multiscale network inference.
We have assembled a team of computational and laboratory research scientists to develop novel tools, reagents, methodologies, and strategies towards the integration of critical disease-related biological networks and network drivers into therapeutics discovery.
The center is developing and using cutting-edge machine-learning and artificial intelligence technologies to integrate single cell and cell-type-specific multi-omics biological datasets, imaging features, small molecule drug libraries, and clinical information into integrative analytical models. These technologies will provide a better understanding of the fundamental questions about the genetic architecture and pathogenesis of complex diseases and further identify potential causal regulators or molecular drivers involved in etiopathogenesis that are likely meaningful therapeutic targets.
In parallel, the center develops and implement in vitro and in vivo experimental models, such as human induced pluripotent stem cell models and animal disease models, to validate the identification of select molecular drivers as candidate therapeutic targets. This will potentially develop useful therapeutic lead compounds targeting the validated drivers. Collectively, our research mission will support the design of novel therapeutic trials for diverse complex diseases.
Recent Grants – Novel Network Biology Approaches to Reposition FDA-approved Drugs for Alzheimer’s Disease (1T-R01-AG068030)
Recent Publications – The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer’s disease
Mount Sinai Clinical Intelligence Center
Director – Alexander Charney
Description
The Mount Sinai Clinical Intelligence Center (MSCIC) represents a diverse group of data scientists, engineers, clinical physicians and researchers who joined together in the Spring of 2020 to commit their expertise to combat the Covid-19 pandemic in our community. Having risen organically amidst tragedy – is uniquely positioned to bring to life the long-promised dream of providing data analytic solutions to MSHS that will not only allow us to combat the current threat of Covid-19 but also ensure Mount Sinai is battle-ready for future crises.
Recent Grants – A multiscale investigation of the living human brain (1T-R01-AG069976)
Recent Publications – Anticoagulation, Bleeding, Mortality, and Pathology in Hospitalized Patients With COVID-19
Nash Family Center for Advanced Circuit Therapeutics
Director – Helen S Mayberg, MD
Description
Vision: A shared ecosystem of clinicians, neuroscientists and engineers will catalyze a new model of patient-focused research with the common goal to correct circuit abnormalities and restore mood, motor and cognitive function across diagnoses.
For too many patients struggling with the daily challenges of a psychiatric or neurologic disorder, today’s therapies simply aren’t enough. The Nash Family Center for Advanced Circuit Therapeutics is committed to developing bold, new approaches for the treatment of conditions from major depression and addiction to eating disorders and post-traumatic stress syndrome to movement disorders and epilepsy as well.
The center’s research looks beyond pharmacological therapies to instead focus on understanding and correcting the circuit-based mechanisms of these diseases. Combining innovative technologies (including deep brain stimulation and advanced imaging) with the experience of a multidisciplinary team (including researchers and clinicians in neurology, neurosurgery, psychiatry, and radiology), our Center is working toward the day when precision, circuit-based treatments help patients to finally move beyond their condition and enjoy life to the fullest.
Recent Grants – Electrophysiological Biomarkers to Optimize DBS for Depression (5T-UH3-NS103550)
Recent Publications – Treatment resistant depression: A multi-scale, systems biology approach
Population Health - Division of Epidemiology
Director – Emanuela Taioli, PhD
Description
The Division of Epidemiology brings together scientists working on clinical, social, and applied epidemiology. Faculty are engaged in highly collaborative translational and interdisciplinary research integrating population studies, genomic and proteomic research. The Division is closely connected with the Institute for Translational Epidemiology
Recent Grants – Thyroid Cancer Aggressiveness in WTC Responders (5T-U01-OH011849P)
Recent Publications – Mesothelioma: Scientific clues for prevention, diagnosis, and therapy
Research Informatics Core
Director – Ron Levitan
Description
Advances in information technology continue to have a profound impact on the conduct of healthcare research. Our mission is to evaluate, develop and provide novel IT solutions to problems in healthcare research, with an emphasis on the development of web-based systems to support novel clinical trials and observational study designs. Our electronic data capture (EDC) systems provide features to support complex data entry, with reporting and notification workflows involving core labs, event adjudication committees, sponsors and regulatory agencies.
Recent Grants – N/A
Recent Publications – Mitral-valve repair versus replacement for severe ischemic mitral regurgitation
Research Information Technology
Director – Ashish Narayan
Description
Mount Sinai’s Research Information Technology department provides services and resources to support the research institutes, centers, and laboratories within the Icahn School of Medicine at Mount Sinai. Through our tools and guidance, we meet your information technology needs through every step of the research process.
Recent Grants – N/A
Recent Publications – Advancing the Use of Mobile Technologies in Clinical Trials: Recommendations from the Clinical Trials Transformation Initiative.
Scientific Computing and Data | Icahn School of Medicine
Scientific Computing and Data | Icahn School of Medicine
Director – Patricia Kovatch
Description
We engage and collaborate with researchers and clinicians to achieve extraordinary biomedical breakthroughs. Genomics, molecular biology, oncology, and psychiatry are just a few of the fields in which scientists have used our expertise and resources to achieve new discoveries at speeds that were unthinkable only a few years earlier. In addition, researchers are devising more complex experiments, higher fidelity simulations, and attaining a higher level of accuracy.
Recent Grants – Data Repository and Management Core (5T-U2C-ES026555)
Recent Publications – An inflammatory cytokine signature predicts COVID-19 severity and survival
Sinai AppLab | Creating Appiness Together!
Director – Ashish Atreja, MD, MPH
Description
Seeing the need for medical applications, Dr. Ashish Atreja founded the Sinai AppLab in 2012 at Mount Sinai Health System in New York City. By 2013, our first grant was awarded, closely followed by more. The Sinai AppLab now boasts extensive experience creating, implementing and evaluating technology platforms to address the needs of patients, health care providers, and researchers within the Mount Sinai Health System and beyond. The AppLab has a 10 member full-time technical team including a clinical informaticist, UX designer, app developers, and data analyst. Over the course of the last five years, Sinai AppLab has been awarded many grants from NIH, CDC, the City and State of New York, foundations, and industry. This support has allowed us to develop several health IT apps and to connect them into a digital health infrastructure.
Recent Grants – Translating Scientific Evidence into Practice using Digital Medicine and Electronic Patient Reported Outcomes (1T-U01A-TR002997)
Recent Publications – Remote Patient Monitoring in IBD: Current State and Future Directions