The Mount Sinai Exposomics Core centers around The Institute for Exposomic Research at the Icahn School of Medicine at Mount Sinai, which was established in 2017 under the leadership of Robert O. Wright, MD, MPH and Rosalind J. Wright, MD, MPH, international leaders in exposomics environmental health. It focuses on unique resources, talented scientists and clinicians, and supports collaborations across departments and institutes at Mount Sinai. The environment plays a role in all human diseases, even genetic disorders such as cystic fibrosis or sickle cell anemia, as we all live in a world of chemicals, variable nutrition/air, water quality and social media. An individual with sickle cell or cystic fibrosis exposed to air pollution or chemicals that cause inflammation will develop exacerbation to disease that can be avoided by greater understanding of environmental principles. We are dedicated to developing protocols, workshops and courses that disseminate these principles to researchers, healthcare professionals and patients.
The Exposomics Core aims to:
- Educate and train translational researchers in the scientific principles and methodologies of exposomics by hosting a series of didactics, case-based seminars, and workshops introducing translational researchers to exposomic science in clinical research. They will create a new graduate school course on exposomic science that introduces trainees, including CTSA TL1 and KL2 scholars, to these principles.
- Disseminate best practices and open-source tools to accelerate clinical exposomic research and enhance collaborations to the broader CTSA Network. Their efforts will be local via formation of exposomic consultation teams, regional through a growing collaboration with CTSA Hubs in the Northeast and Midwest, national through the Direct2Experts research social network, and international via an annual exposomics symposium. They will also create an exposomic web portal that disseminates educational materials and open-source tools, including a novel Geoserver. These efforts will promote access to expertise and resources that can be applied to clinical research, accelerating growth of exposomic research in translational science.
Their mission is to accelerate exposomic research, improving health care through innovative approaches to disease prevention and treatment. Exposomics will aid clinical researchers in the discovery of disease mechanisms as well as the environmental causes of variable responses to treatments. Exposomics will enable clinicians to select and apply the most effective and safest therapies while minimizing treatment failures and complications, thereby making precision medicine even more precise.
Exposomics Core Team
- Robert Wright
- Itai Kloog
- Dinesh Barupal
- Lauren Petrick
- Manish Arora
ConduITS is supported by NCATS of the NIH’s CTSA Program. Any use of CTSA-supported resources requires citation of grant number UL1TR004419 awarded to ISMMS in the acknowledgment section of every publication resulting from this support. Adherence to the NIH Public Access Policy is also required.
