Dr. Lesseur is a molecular epidemiologist and bioinformatician with research interests in multi-omics (epi/genomics) and gene-environment interactions in relation to early-life, pregnancy, and cancer outcomes. Currently, she is an Assistant Professor in the Dept. of Environmental Medicine and Climate Science, at the Icahn School of Medicine at Mount Sinai. Dr. Lesseur is particularly interested in characterizing the molecular landscape of the human placenta and how it is affected by environmental exposures and pregnancy complications possibly mediating the role of the placenta in future disease programming, with consequences for both mothers and infants. She has worked in multiple studies evaluating placental DNA methylation and/or gene expression in relation to maternal and infant outcomes, with >25 publications on the topic. Dr. Lesseur has extensive training in handling, analyzing, and integrating large-scale genotype, DNA methylation and RNA-seq datasets from population-based studies.
Dr. Lesseur’s study titled Exploring associations between the placental transcriptome and maternal postpartum depressive symptoms aims to leverage existing placental samples from mother-infant pairs in the ongoing Generation C-SF birth cohort in the Mount Sinai Hospital to:
- Investigate associations between the placental transcriptome and 3-month postpartum Edinburgh Postnatal Depression Scale (EPDS) scores using a gene co-expression network approach.
- Investigate associations between candidate neuro-immune-endocrine genes and maternal EPDS scores (3-month postpartum).
ConduITS is supported by NCATS of the NIH’s CTSA Program. Any use of CTSA-supported resources requires citation of grant number UL1TR004419 awarded to ISMMS in the acknowledgment section of every publication resulting from this support. Adherence to the NIH Public Access Policy is also required.
