The National Institutes of Health (NIH) launched the Trial Innovation Network (TIN) in 2017 to help researchers carry out multicenter clinical trials better, faster and more cost-efficiently, and to create a national laboratory to study, understand and innovate the process of conducting clinical trials.
The ConduITS Institutes for Translational Sciences at Mount Sinai has established a local TIN Hub Liaison Team (THLT) to assist ISMMS investigators to better understand and utilize the TIN.
The ISMMS TIN Hub Liaison Team also provides consultations for individuals requiring multi-site support to assist in determining if we have the resources internally or if investigators should use the TIN.
The TIN offers guidance for multi-center studies like navigation of the single IRB process, input on protocol development, master contracting agreements, quality by design approaches, and a focus on evidence-based strategies to recruitment and patient engagement.. TIN offers additional services besides sIRB and the initial consultation. Here is a full list. – Initial Consultation and Resources
Characteristics of ideal TIN proposals
- Multi-center study design (three or more institutions)
- Willingness to partner with the TIN through the lifecycle of the project
- An innovative operational approach to improve quality, efficiency, or cost of clinical research
- At least 60 days allotted for consultation prior to planned grant submission with substantial project development
- All populations affected by the health condition being studied, including women, racial/ethnic minorities and children
- The ability to provide academic evidence to improve clinical trial designs, conduct, and reportability.