Determining whether a project is evidence-based practice (EBP), quality improvement (QI), or research can be challenging—even for experts! Some projects that appear to be EBP or QI may contain elements of research. Conversely, some projects that we refer to colloquially as research are actually EBP or QI. Finding the correct determination is important for ensuring that projects are reviewed by the appropriate bodies since research projects require Institutional Review Board (IRB) review while EBP and QI projects do not. This guide is designed to clarify the definitions of EBP, QI, and research, and to provide insight into which projects meet the definition of research.