PROMIS (Patient-Reported Outcome Measurement Information System) is a joint ConduITS Clinical & Translational Science Award and The Office of Chief Research Informatics Officer (CRIO) program which provides dynamic tools to measure health outcomes from the patient perspective. These tools are comprised of highly reliable, precise measures of patient-reported health status for physical, mental, and social well-being. This resource can be used to measure health symptoms and health-related quality of life domains such as pain, fatigue, depression, and physical function, which are relevant to a variety of clinical trials supported at Mount Sinai.

Clinical measures of health outcomes may have little relevance to the day-to-day functioning of patients with chronic diseases. Often, the best way patients can judge the effectiveness of treatments is by changes in their symptoms. This feedback or data is called Patient Reported Outcomes. The Patient Reported Outcome Measurement Information System (PROMIS) is a system built on something called item response theory.

PROMIS was established in 2004 as a NIH-funded initiative to develop and validate patient reported outcomes for clinical research and practice. It developed into a cooperative network that has had a substantial impact, with approximately 70 domains measuring pain, fatigue, depression, anxiety, sleep disturbance, physical function, social function, and sexual function, among other areas, available for use today. Measures were developed for children and adults, and has been translated into >40 languages (including English and Spanish). The work surrounding PROMIS has resulted in over 400 publications. More than 100 NIH grants have supported investigations using PROMIS instruments. PROMIS is available in a variety of forms, including paper and pencil, web and mobile platforms, as well as via electronic health record (EHR) data capture.

An example of what forms Mount Sinai is currently able to implement can be found at this link:

http://researchroadmap.mssm.edu/wp-content/uploads/2020/12/PROMIS-surveys.pdf

Link to the website that expands upon this overview can be found at:

https://www.healthmeasures.net/explore-measurement-systems/promis

ConduITS is supported by NCATS of the NIH’s CTSA Program. Any use of CTSA-supported resources requires citation of grant number UL1TR001433 awarded to ISMMS in the acknowledgment section of every publication resulting from this support. Adherence to the NIH Public Access Policy is also required.